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Advances in Down Syndrome Research

Gert Lubec

$370.95   $296.98

Paperback

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English
Springer Verlag GmbH
19 December 2003
""Advances in Down Syndrome Research” represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes.
Edited by:  
Imprint:   Springer Verlag GmbH
Country of Publication:   Austria
Edition:   Softcover reprint of the original 1st ed. 2003
Volume:   67
Dimensions:   Height: 279mm,  Width: 210mm,  Spine: 14mm
Weight:   643g
ISBN:   9783211407769
ISBN 10:   3211407766
Series:   Journal of Neural Transmission. Supplementa
Pages:   242
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active

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