A Probabilistic Model of the Genotype/Phenotype Relationship: Does Life Play the Dice?

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Jean-Pierre Hugot (Université Paris Diderot Sobonne Paris-Cité; and Head, Department of Pediatric Gastroenterology, Robert Debré Hospital, Paris, France) Clare Davis

A Probabilistic Model of the Genotype/Phenotype Relationship

Does Life Play the Dice?

Jean-Pierre Hugot (Université Paris Diderot Sobonne Paris-Cité; and Head, Department of Pediatric Gastroenterology, Robert Debré Hospital, Paris, France), Clare Davis

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English

CRC Press
31 March 2021

Human reproduction, growth & development; Genetics (non-medical); Developmental biology; Molecular biology; Cellular biology (cytology)

A Probabilistic Model of the Genotype/Phenotype Relationship provides a new hypothesis on the relationship between genotype and phenotype. The main idea of the book is that this relationship is probabilistic, in other words, the genotype does not fully explain the phenotype. This idea is developed and discussed using the current knowledge on complex genetic diseases, phenotypic plasticity, canalization and others.

By: Jean-Pierre Hugot (Université Paris Diderot Sobonne Paris-Cité; and Head Department of Pediatric Gastroenterology Robert Debré Hospital Paris France)
Translated by: Clare Davis
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 272g
ISBN: 9780367781033
ISBN 10: 0367781034
Pages: 164
Publication Date: 31 March 2021
Audience: College/higher education , General/trade , Primary , ELT Advanced
Format: Paperback
Publisher's Status: Active

1.Introduction: complex genetic diseases. Part 1: The Genotype / Phenotype Relationship. 2. Genetic program and self-organization. 3. The share of the environment. 4. Analogy between organisms and particles. 5. Phenotypic Plasticity. 6. Behavior. Part2: Heredity. 7. Reproduction and Phenotypic Canalization. 8. Fertilization and overlapping of genotypes. 9. Nature of canalization. 10.Canalization : experimental data. 11. Implications of canalization. 12. Canalization and instinct. Part 3: Evolution. 13. Limits to naturalselection. 14. Instinct and evolution. 15. Biological function. 16. Differentiation and phenotypic coherence. 17. Speciation. 18.Phenotypic innovation. 19. Conclusion. 20. In summary. 21. Bibliography.