The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values.
The anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values.
The main task of the basal ganglia-a group of subcortical nuclei, located at the base of the brain-is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson's disease and other ganglia-related disorders, and such therapies as deep brain stimulation.
Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia-related disorders and their treatments, including Parkinson's disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.
By:
Hagai Bergman
Imprint: MIT Press
Country of Publication: United States
Dimensions:
Height: 254mm,
Width: 178mm,
Weight: 368g
ISBN: 9780262543118
ISBN 10: 0262543117
Pages: 288
Publication Date: 05 January 2022
Audience:
General/trade
,
ELT Advanced
Format: Paperback
Publisher's Status: Active
Preface xi Acknowledgments xiii I Introduction and Background 1 The Basal Ganglia: Why and Where? 3 2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15 3 The Synaptic Connections of the Basal Ganglia Network 27 4 Computational Modeling of Brain and Behavior 39 5 Principles of Neurophysiological Data Acquisition 43 6 Principles of Neurophysiological Analysis 61 II Computational Physiology of the Healthy Basal Ganglia 7 Physiology of the Basal Ganglia 77 8 Basal Ganglia Physiology: The Roads Less Traveled 89 9 Box-and-Arrow Rate Models of the Basal Ganglia 105 10 Reinforcement-Learning Actor/Critic Models of the Basal Ganglia 117 11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133 12 The Basal Ganglia as one of many State-to-Action Loops 145 III Computational Physiology of Basal Ganglia Disorders and their Therapy 13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163 14 Animal Models of Parkinson's Disease 171 15 Physiology of Parkinson's Disease: Animal Models 179 16 Physiology of Parkinson's Disease: Human 195 17 Pharmacotherapy of Parkinson's Disease 203 18 Deep Brain Stimulation Therapy for Parkinson's Disease 215 19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225 IV From the Basal Ganglia and Brain to the Mind 20 The Basal Ganglia, Free Will, and Human Responsibility 241 Notes 247 References 261 Index 295
Hagai Bergman is Simone and Bernard Guttman Chair in Brain Research and Professor of Physiology in the Edmond and Lily Safra Center (ELSC) for Brain Research and Faculty of Medicine at the Hebrew University of Jerusalem.
