Molecular Pharmacology: From DNA to Drug Discovery

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John Dickenson (Nottingham Trent University) Fiona Freeman (Nottingham Trent University)

Molecular Pharmacology

Name: Molecular Pharmacology
Price: 251.95 AUD
Availability: OutOfStock
ISBN: 9780470684443

From DNA to Drug Discovery

John Dickenson (Nottingham Trent University), Fiona Freeman (Nottingham Trent University), Chris Lloyd Mills (Nottingham Trent University) , Christian Thode (Nottingham Trent University)

$251.95

Hardback

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English

John Wiley & Sons Inc
19 December 2012

Pharmacology; DNA & Genome; Molecular biology

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.

Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell.

Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.

By: John Dickenson (Nottingham Trent University), Fiona Freeman (Nottingham Trent University), Chris Lloyd Mills (Nottingham Trent University), Christian Thode (Nottingham Trent University), Shiva Sivasubramaniam (Nottingham Trent University)
Imprint: John Wiley & Sons Inc
Country of Publication: United States
Dimensions: Height: 254mm, Width: 196mm, Spine: 25mm
Weight: 1.071kg
ISBN: 9780470684443
ISBN 10: 0470684445
Pages: 424
Publication Date: 19 December 2012
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

John Dickenson, Fiona Freeman, Chris Lloyd Mills, Shiva Sivasubramaniam and Christian Thode, all at Nottingham Trent University.

Reviews for Molecular Pharmacology: From DNA to Drug Discovery

<p> An informative, comprehensive text, it is highlyrecommended to postgraduates and researchers in both pharmacologyand molecular biology. (Science Progress, 1March 2014) <p> Overall, it could be the basis of an excellent course forjunior pharmacologists in basic science research who need a greaterfocus on the mechanisms of drug action rather than an encyclopedicsurvey of clinical drug use. (Doody s, 26July 2013)