DRUG TRANSPORTERS
Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.
Reflects the current state of the field and offers perspectives on future directions Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science Provides up-to-date information on drug transporter families, mechanisms, and clinical implications Includes extensive references and numerous figures and tables throughout
Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.
List of Contributors Preface CHAPTER 1. Overview of Drug Transporter Families Guofeng You and Marilyn E. Morris CHAPTER 2. Organic Cation and Zwitterion Transporters Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. Giacomini CHAPTER 3. Multidrug and Toxin Extrusion Proteins Lauren M. Aleksunes, Victoria Woo, and Melanie S. Joy CHAPTER 4. Organic Anion Transporters (OATs) Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam CHAPTER 5. Organic Anion Transporting Polypeptides OATP Rommel G. Tirona and Richard B. Kim CHAPTER 6. Mammalian Oligopeptide Transporters Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp. CHAPTER 7. Monocarboxylic Acid Transporters Marilyn E. Morris and Nisha V. Kwatra CHAPTER 8. The Nucleoside Transporters CNTs and ENTs Raj Govindarajan, Antonio López Quiñones, and Joanne Wang CHAPTER 9. Bile Acid Transporters Ebehiremen N. Ayewoh and Peter W. Swaan CHAPTER 10. The P-glycoprotein Multidrug Transporter Andaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar CHAPTER 11. Multidrug Resistance Proteins of the ABCC Subfamily Anne T. Nies and Franziska Klein CHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP) Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates CHAPTER 13. Drug Transport in the Liver Noora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer CHAPTER 14. Drug Transport in the Brain Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan CHAPTER 15. Drug Transport in the Kidney Douglas H. Sweet CHAPTER 16. Drug transporters in the human intestine Stefan Oswald CHAPTER 17. Drug Transport in the Placenta Qingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat CHAPTER 18. Polymorphisms of drug transporters and clinical relevance Tore B. Stage and Deanna L. Kroetz CHAPTER 19. Ontogeny of Drug Transporters Melanie A. Felmlee and Qing Zhang CHAPTER 20. Experimental Approaches for Studying Drug Transporters Yusuke Masuo, Azusa Futatsugi, and Yukio Kato CHAPTER 21. Transporters mediated drug disposition – Physiochemistry and in silico approaches Manthena V. S. Varma, Ayman El-Kattan, and Yurong Lai CHAPTER 22. In vitro-in vivo scale-up of drug transport activities Kazuya Maeda and Yuichi Sugiyama CHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and Toxicity Matthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle Neuhoff CHAPTER 24. Transporters as therapeutic targets in human diseases Robert S. Jones and Eugene C. Chen CHAPTER 25. Diet/Nutrient Interactions with Drug Transporters Marilyn E. Morris and Tianjing Ren Index
Guofeng You, PhD, Distinguished Professor of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA. Marilyn E. Morris, PhD, SUNY Distinguished Professor and Chair, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, USA.
