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English
Oxford University Press Inc
01 November 2004
Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents.

Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.

Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.

Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.
By:  
Imprint:   Oxford University Press Inc
Country of Publication:   United States
Dimensions:   Height: 262mm,  Width: 215mm,  Spine: 53mm
Weight:   849g
ISBN:   9780195181999
ISBN 10:   0195181999
Series:   Computational Neuroscience Series
Pages:   586
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active

Reviews for Biophysics of Computation: Information processing in single neurons

A memoir by Alexander (Nampally Road, 1990), tracing her life from childhood in India through youth and education in Africa and England to marriage and motherhood in Manhattan. Alexander's desire to overcome the torment of her multiple migrations in order to tell her story, however, is undercut by overwriting and an oceanic sentimentality. Beginning the story of her life with the story of this book's writing - an editor's pitch in an Upper West Side cafe; sleepless nights in the author's apartment spent assembling the fragments of a broken geography - Alexander weaves back and forth between present and past, mixing metaphors and memories with abandon. I sit here writing, for I know that time does not come fluid and whole into my trembling hands. All that is here comes piecemeal, though sometimes the joints have fallen into place miraculously, as if the heavens had opened and mango trees fruited in the rough asphalt of upper Broadway. Born in 1951, the first of three daughters of a meteorologist, Alexander was raised in southern India before her father was transferred to the Sudan when she was five. From her summer visits back to her ancestral home, Alexander reconstructs her childhood idyll: There are her adoring and wise maternal grandfather in his garden of mango trees and cashews; her shrewd but affection old ayah (nanny); and the self-contained, genteel world of the joint family household. Forays into the social and political issues raised by postcolonialism and feminism occur throughout the text, but Alexander focuses on her own cultural identity crisis as metaphor for them. In her decision to wear a sari one day and a pair of jeans the next, she implicates the future of cultural difference and the integrity of the nation state. Alexander's view of herself as a sociopolitical microcosm seems far-fetched and self-absorbed; as a result, what might have been a revealing memoir remains a carelessly crafted reverie. (Kirkus Reviews)


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