Neuron Signaling in Metabolic Regulation

Qingchun Tong (University of Texas Health Science Center, TX, USA)

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English

CRC Press
26 June 2023

Medicine: general issues; Endocrinology; Neurosciences; Biochemistry; Cellular biology (cytology)

Series: Methods in Signal Transduction Series

This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis is maintained by balanced food intake and energy expenditure, both of which are under the control of brain neurons. In the recent years, significant progress has been made in identifying specific neurons, neural pathways, and non-neuron cells in feeding regulation, as well as in delineating autonomic nervous systems targeting peripheral metabolic tissues in the regulation of energy expenditure and metabolism. This book reviews recent progress on important neuron signaling for body weight and metabolic regulation and the state-of-the-art methods that has been applied in this field, ranging from animal models with neuron-specific manipulations, pharmacology, optogenetics, in vivo Ca2+ imaging, and viral tracing. Readers will be exposed to latest research frontiers on neuron regulation of metabolism.

Key Features

Explores the role signaling between neurons plays with respect to metabolism

Documents how neurotransmitters affect the regulation of feeding

Describes various methods and technologies used to study the neuronal control of metabolism

Includes contributions from an international team of leading researchers.

Related Titles

Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1)

Feltz, A. Physiology of Neurons (ISBN 978-0-8153-4600-5)

Zempleni, J. & K. Dakshinamurti, eds. Nutrients and Cell Signaling (ISBN 978-0367-39307-6)

Edited by: Qingchun Tong (University of Texas Health Science Center TX USA)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 621g
ISBN: 9780367744663
ISBN 10: 036774466X
Series: Methods in Signal Transduction Series
Pages: 326
Publication Date: 26 June 2023
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Paperback
Publisher's Status: Active

Chapter 1 Regulation of energy balance by hypothalamic cAMP-related signaling Chapter 2 Brain Melanocortins Regulate Weight in Animals and Humans Chapter 3 Neurotransmitter co-transmission in brain control of feeding and body weight Chapter 4 Brain Glucagon-Like Peptide 1 Receptor Influence on Feeding Behavior Chapter 5 Dorsomedial hypothalamic regulation of energy balance and glucose homeostasis: lessons from adeno-associated virus-mediated gene manipulation Chapter 6 The ventromedial hypothalamic nucleus in the regulation of energy homeostasis Chapter 7 Current Genetic Techniques Available for Investigating Feeding Behavior and the Control of Energy Balance Chapter 8 Central action of thyroid hormone on energy metabolism Chapter 9 Oxytocinergic regulation of energy balance Chapter 10 Lessons learned about metabolism from traditional and novel tools to study structure and function of the vagus nerve Chapter 11 Neuronal regulation of adipose tissue biology Chapter 12 Sex Differences in Feeding Regulated by Estrogen: Crosstalk between Dopaminergic Reward Circuitry and Adiposity Signals Chapter 13 High Throughput Evaluation of Metabolic Activities Using Reverse Phase Protein Array (RPPA) Technology