Nature's Gift to Neuroscience

A Tribute to Sydney Brenner and John Sulston

Chun-Fang Wu (University of Iowa), Joy Alcedo (Wayne State University)

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English

CRC Press
27 May 2024

Neurology & clinical neurophysiology; Neurosciences; Developmental biology; Molecular biology

In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community that uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages – from a single cell to the multicellular adult – which transformed the field of developmental biology.

As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs, or how this animal’s survival strategies have contributed to our understanding of ageing and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity.

The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.

Edited by: Chun-Fang Wu (University of Iowa), Joy Alcedo (Wayne State University)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 280mm, Width: 210mm,
Weight: 690g
ISBN: 9781032145228
ISBN 10: 1032145226
Pages: 356
Publication Date: 27 May 2024
Audience: Professional and scholarly , College/higher education , Undergraduate , Further / Higher Education
Format: Paperback
Publisher's Status: Active

Chun-Fang Wu is Editor-in-Chief of the Journal of Neurogenetics. He has conducted neurobiological research in Drosophila, applying genetic, cell biological, physiological, and behavioural techniques in the studies. Joy Alcedo is Guest Editor for the C. elegans special issue of the Journal of Neurogenetics. Her research focuses on the sensory and neuromodulatory influences on C. elegans development and survival programs.