Recognition of the importance of complex oligosaccharides in a variety of biological processes has stimulated a massive effort to synthesize them. This work presents a review of oligosaccharide synthesis leading from classical methods through to the state-of-the-art technology. The provision, wherever possible, of methods on synthesis and the 17,000 references allow the reader to implement the techniques described. Included are chapters describing the synthesis of the important glycosidic linkage analogs of natural sugars. While the chemical-synthetic methods constitute the main body of the book, completing the volume is a section on the rapidly expanding and important field of enzymatic synthesis.
By:
Shaheer H. Khan
Edited by:
Roger A. O'Neill
Imprint: Harwood-Academic Publishers
Country of Publication: Switzerland
Volume: v. 1
Dimensions:
Height: 246mm,
Width: 174mm,
Spine: 37mm
Weight: 1.424kg
ISBN: 9783718657858
ISBN 10: 3718657856
Pages: 576
Publication Date: 01 March 1996
Audience:
College/higher education
,
Professional and scholarly
,
Further / Higher Education
,
Undergraduate
Format: Hardback
Publisher's Status: Active
1. Twenty Five Years of Carbohydrate Chemistry; An Overview of Oligosaccharide Synthesis 2. The Anomeric O-Alkylation and the Trichloroacetimidate Method - Versatile Strategies for Glycoside Bond Formation 3. Synthesis of Glycosyl Halides for Oligosaccharide Synthesis Using Dihalogenomethyl Methyl Ethers 4. Glycosylation Properties and Reactivity of Thioglycosides, Sulfoxides, and other S-glycosides: Current Scope and Future Prospects 5. Phenyl Selenoglycosides as Versatile Glycosylating Agents in Oligosaccharide Synthesis and the Chemical Synthesis of Disaccharides Containing Sulfur and Selenium 6. Synthesis and Use of S-Xanthates, Carbohydrate Enol Ethers and and Related Derivatives in the Field of Glycosylation 7. n-Pentenyl Glycosides in Oligosaccharide Synthesis 8. Coupling of Glycals: A New Strategy for the Rapid Assembly of Oligosaccharides 9. Advances in Polymer-Supported Solution Synthesis of Oligosaccharides 10. Protecting Groups in Oligosaccharide Synthesis 11. Synthesis of ss-D-Mannose Containing Oligosaccharides 12. Synthesis of Sialoglycoconjugates 13. Synthetic Studies on Cell-Surface Glycans: An Approach to O-linked Sialoglycoprotein 14. Synthesis of C-Glycosides; Stable Mimics of O-Glycosidic Linkages 15. Recent Developments in Glycopeptide Synthesis 16. Design and Synthesis of Glycoconjugates 17. Synthesis of Biologically Active Sulfated and Phosphorylated Oligosaccharides 18. Synthetic Glycosyltransferase Acceptors and Inhibitors; Useful Tools in Glycobiology 19. Practical Synthesis of Oligosaccharides Based on Glycosyltransferases and Glycosylphophites 20. Use of Glycosyltransferases in the Synthesis of Unnatural Oligosaccharide Analogues 21. Synthesis with Glycosidases
Shaheer H. Khan (Applied Biosystems, Forster City, California, USA) (Author)
