Handbook of Lipid Bilayers

Derek Marsh

$588

Hardback

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English

CRC Press Inc
15 February 2013

Physics; Lipids

Phospholipid bilayers are one of the primary building blocks of biomembranes while phospholipid liposemes are critically important for their role in the encapsulation and delivery of pharmaceutical drugs. Written by a world-renowned expert in the field, this handbook provides the only single source for primary physicochemical data relating to phospholipid bilayers. It is an indispensable reference for anyone using bilayer model membranes and liposome delivery systems and for those interested in the biophysics of membrane structure. Coverage includes both dynamic and structural properties of phospholipid bilayers, along with basic thermodynamic data.

The author begins with an introduction to basic properties of phospholipids and their nomenclature. The next several chapters discuss the phase behavior of phospholipid-water systems and the equilibrium properties of bilayers. The book also presents a detailed treatment of the dynamics of transfer between bilayers and transformation to nonbilayer phases that are relevant to membrane fusion processes. Each data section is preceded by an introduction to the measurements. Comparable data are also included for glycolipids, the other bilayer-forming lipid component of biological membranes.

By: Derek Marsh
Imprint: CRC Press Inc
Country of Publication: United States
Edition: 2nd edition
Dimensions: Height: 276mm, Width: 219mm, Spine: 66mm
Weight: 2.267kg
ISBN: 9781420088328
ISBN 10: 1420088327
Pages: 1174
Publication Date: 15 February 2013
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Hardback
Publisher's Status: Active

INTRODUCTION: Lipid Classification. Nomenclature of Lipids. Fatty Acids. PHOSPHOLIPIDS: Phospholipid Classification and Molecular Weights. Fatty Acid Composition of Naturally Occurring Phospholipids and of Membrane Lipids from the Yeast Lipidome. Physicochemical Properties of Phospholipids. Phospholipid pKas. Crystal Structures of Phospholipids. Phase Behavior and Hydration. Calorimetric Data. X-Ray Diffraction Data. Densitometric Data. Elastic Constants. Dynamic Properties. Phase Transition Temperatures. Phase Diagrams: Binary and Ternary Mixtures. Non-Lamellar Phases (Hexagonal and Cubic). Critical Micelle Concentrations and Lipid Transfer. Bilayer-Bilayer Interactions. Ion-Binding Constants. GLYCOLIPIDS: Glycolipid Classification and Molecular Weights. Fatty Acid Composition of Naturally Occurring Glycolipids. Physicochemical Properties of Glycolipids. Glycolipid pKas. Crystal Structures. Phase Behavior and Hydration. Calorimetric Data. X-Ray Diffraction Data. Densitometric Data. Elastic Constants. Dynamic Properties. Phase Transition Temperatures. Phase Diagrams: Binary Mixtures. Non-Lamellar Phases (Hexagonal and Cubic). Critical Micelle Concentrations and Lipid Transfer. Bilayer-Bilayer Interactions. Ion-Binding Constants.

Derek Marsh is a member of the research staff of the Max Planck Institute for Biophysical Chemistry, Göttingen. Dr. Marsh obtained his B.A. degree in physics from the University in Oxford in 1967 and his D.Phil. degree from the same institution in 1971. He worked subsequently at the Astbury Department of Biophysics, University of Leeds; at the Biology Division of the National Research Council of Canada, Ottawa; at the Max Planck Institute in Göttingen; and at the Biochemistry Department of the University of Oxford, before moving permanently to Göttingen in 1975. Dr. Marsh's research interests centre on studies of the structure and dynamics of biological membranes and of lipid bilayer model membranes, using different biophysical techniques, the principal being spin-label electron paramagnetic resonance spectroscopy.

Reviews for Handbook of Lipid Bilayers

"""It is no wonder that the book was published by CRC Press, with the vast amount and superior quality of the information contained therein. The work has been dramatically expanded and updated from the first edition, and is fortunately now in print once again."" —Matthew D. Metcalf, Pharm.D, Ph.D, Assistant Professor of Medicinal Chemistry, Massachusetts College of Pharmacy and Health Sciences University, Worcester, USA, from HerbalGram"

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Handbook of Lipid Bilayers

Derek Marsh

$588

Hardback

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