Epigenetic Mechanisms in Cancer

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Sabita Saldanha (Assistant Professor, Department of Biological Sciences, Alabama State University, Montgomery, AL, USA)

Epigenetic Mechanisms in Cancer

Sabita Saldanha (Assistant Professor, Department of Biological Sciences, Alabama State University, Montgomery, AL, USA)

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English

Academic Press Inc
07 November 2017

Medical genetics; Genetics (non-medical); DNA & Genome; Genetic engineering

Series: Translational Epigenetics

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

Edited by: Sabita Saldanha (Assistant Professor Department of Biological Sciences Alabama State University Montgomery AL USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
Weight: 1.000kg
ISBN: 9780128095522
ISBN 10: 0128095520
Series: Translational Epigenetics
Pages: 392
Publication Date: 07 November 2017
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Dr. Saldanha is an Assistant Professor in the Department of Biological Sciences at Alabama State University. Her current research project includes the therapeutic role of histone deacetylase inhibitors in colon and prostate cancers, and her areas of epigenetic interest include epigenetic markers as effective tools in cancer diagnosis. She has more than fifteen years of research experience in cancer epigenetics, protein biochemistry, molecular biology and cloning. She has twelve years of teaching experience and has been a STEM faculty mentor, MARC mentor, and Honor’s program project director at ASU. Recently, Dr. Saldanha was named the 2015 National Academies Education Fellow in Life Sciences. She is also currently a Health Disparities Research and Training Program Scholar at UAB and a member of the Cancer Biology Research and Training program at ASU, which was established in 2015. She serves as senior personnel for the ASU-UAB Comprehensive Cancer Center partnership and has been instrumental in developing a cancer biology course at ASU.