Chemical Biology of the Genome

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Siddhartha Roy (Founder-President of Chemical Biology Society, India) Tapas K. Kundu (Silver Jubilee Professor, Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, India)

Chemical Biology of the Genome

Siddhartha Roy (Founder-President of Chemical Biology Society, India), Tapas K. Kundu (Silver Jubilee Professor, Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, India)

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English

Academic Press Inc
19 May 2021

Biophysics; DNA & Genome; Enzymology; Molecular biology

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome.

Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs.

By: Siddhartha Roy (Founder-President of Chemical Biology Society India), Tapas K. Kundu (Silver Jubilee Professor, Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, India)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
Weight: 720g
ISBN: 9780128176443
ISBN 10: 012817644X
Pages: 350
Publication Date: 19 May 2021
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Prof. Siddhartha Roy is a renowned scientist in the field of Chemical Biology. He has made significant contributions in the area of transcription regulation. He was the Director of CSIR-Indian Institute of Chemical Biology (IICB), the first institution dedicated to Chemical Biology, for a decade. He is the Founder-President of Chemical Biology Society, India. Prof. Tapas K. Kundu has made outstanding contributions in the area of Epigenetic regulation of gene expression in humans in the context of disease and therapeutics. He has discovered several small molecule modulators of Epigenetic enzymes.