Algorithms in Structural Molecular Biology

Bruce R. Donald (Professor, Duke University)

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English

MIT Press
15 August 2023

Molecular biology; PDA & Handheld programming

Series: Computational Molecular Biology

An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.

Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted- NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

By: Bruce R. Donald (Professor Duke University)
Imprint: MIT Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 203mm,
Weight: 454g
ISBN: 9780262548793
ISBN 10: 0262548798
Series: Computational Molecular Biology
Pages: 464
Publication Date: 15 August 2023
Recommended Age: From 18 years
Audience: College/higher education , Primary
Format: Paperback
Publisher's Status: Active

Bruce R. Donald is William and Sue Gross Professor of Computer Science at Duke University and Professor of Biochemistry in the Duke University Medical Center. His laboratory is associated with Duke's Program in Computational Biology and Institute for Genome Sciences and Policy.