Theoretical Biology of the Cell: A Dynamical-Systems Perspective

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Hiroaki Takagi (Nara Medical University) Chikara Furusawa (The University of Tokyo)

Theoretical Biology of the Cell

A Dynamical-Systems Perspective

Hiroaki Takagi (Nara Medical University), Chikara Furusawa (The University of Tokyo), Satoshi Sawai (The University of Tokyo) , Kunihiko Kaneko (Copenhagen University)

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English

Cambridge University Press
19 June 2025

Biophysics

To understand life phenomena, we must consider form, structure, organization, motion, and the roles they play in “living” functions. This book explores such elements through mathematical methods. Beginning with an overview of dynamical systems and stochastic processes, the chapters that follow build on experimental advances in quantitative data in cellular processes to demonstrate the applications of these mathematical methods to characterize living organisms. The topics covered include not only cellular motions but also temporal changes in metabolic components, protein levels, membrane potentials, cell types, and multicellular patterns, which are linked to functions such as cellular responses, adaptation, and morphogenesis. This book is intended for undergraduates, graduates, and researchers interested in theory and modeling in biology, in particular cell, developmental, and systems biology, also those in the fields of mathematics and physics who are interested in these topics.

By: Hiroaki Takagi (Nara Medical University), Chikara Furusawa (The University of Tokyo), Satoshi Sawai (The University of Tokyo), Kunihiko Kaneko (Copenhagen University)
Imprint: Cambridge University Press
Country of Publication: United Kingdom
ISBN: 9781009397841
ISBN 10: 1009397842
Pages: 326
Publication Date: 19 June 2025
Audience: General/trade , ELT Advanced
Format: Paperback
Publisher's Status: Active

Hiroaki Takagi is a Senior Assistant Professor of Physics at Nara Medical University, and a core member of Q-bioJP. His expertise lies in biophysics and nonlinear dynamics. He is interested in the functional significance of fluctuations and dynamics at molecular, cellular, and multicellular levels. Through analyses combining quantitative biological data and mathematical models, his research seeks to elucidate their mechanisms. Chikara Furusawa is a Professor at the University of Tokyo and a team leader at RIKEN. His research aims to uncover universal characteristics in biological systems by combining theoretical analysis with high-throughput experimental approaches. His primary areas of study include evolutionary dynamics, cell differentiation, and metabolic dynamics, among others. Satoshi Sawai is a Professor at the University of Tokyo. He has been fascinated with the slime mold Dictyostelium for more than two decades, considering it a hidden gem filled with mathematical ideas and concepts, which are covered in this book. Kunihiko Kaneko has been a Professor at the University of Tokyo for twenty-seven years, teaching mathematical biology and nonlinear dynamics, and he is currently at the Niels Bohr Institute. He was also Stanislaw Ulam Fellow at Los Alamos National Laboratory, visiting professor at Osaka University (Frontier Biosciences), University of Lyon, and Freiburg University, and is a Founding Director of Center for Complex Systems Biology and Universal Biology Institute at the University of Tokyo.

Reviews for Theoretical Biology of the Cell: A Dynamical-Systems Perspective

'The explosion of quantitative biology creates novel pedagogical challenges. Takagi et al. have delivered an exciting textbook covering standard topics in dynamical systems theory such as feedback loops in cell systems, but also more advanced topics, such as pattern formation, number fluctuations of biomolecules, and even the origin of life and the role of information in biology. This book is unique in its ability to inspire, as well as in its depth and clarity. I would enjoy teaching and learning from it and so will you!' Nigel Goldenfeld, University of California San Diego