The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

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Brent Stockwell

The Quest for the Cure

The Science and Stories Behind the Next Generation of Medicines

Brent Stockwell

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English

Columbia University Press
01 June 2011

Medicine; Pharmacology

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.

Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research.

Scientists such as Stockwell are now developing methods to combat these complexities-technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules-all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

By: Brent Stockwell
Imprint: Columbia University Press
Country of Publication: United States
Dimensions: Height: 210mm, Width: 140mm, Spine: 24mm
Weight: 440g
ISBN: 9780231152129
ISBN 10: 0231152124
Pages: 284
Publication Date: 01 June 2011
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Brent R. Stockwell is an associate professor of biological sciences and chemistry at Columbia University and a Howard Hughes Medical Institute Early Career Scientist. He serves on the editorial board of Chemistry & Biology, has been awarded ten U.S. patents, and has published fifty-four scientific papers. Among his recent honors are a Burroughs Wellcome Fund Career Award at the Scientific Interface and a Beckman Young Investigator Award.

Reviews for The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

<p>This is a terrific book! Stockwell's writing is clear and engaging as he presents a thoughtful analysis of drug development that can be understood and appreciated by a diverse readership. Stockwell beautifully combines scientific history and personal anecdotes with clear explanations of the principles and practices of chemical biology to make a fascinating story of the past, present, and future of drug discovery. His book is informative, accurate, and a good read all put together.--Geoffrey Cooper, Boston University, author of The Cell: A Molecular Approach and Oncogenes