The Physical Measurement of Bone

C.M. Langton, C.F. Njeh

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English

Institute of Physics Publishing
01 December 2003

Physiology; Medical physics

Series: Series in Medical Physics and Biomedical Engineering

There are a wide variety of methods applied in the physical analysis of bone in vivo and in vitro. Each method has its own uses and strengths depending on the information sought by the clinician or researcher. This book provides a detailed description of all the major methods of bone analysis, aimed at medical physicists and not clinicians, it details the physics of the processes and techniques employed in obtaining the measurements, with brief comments on clinical evaluation. It will appeal to practising medical physicists who need to know about the many methods of analysis open to them, and more importantly the wide coverage will provide a good introductory text to students of medical physics and biomedical engineering.

Edited by: C.M. Langton, C.F. Njeh
Imprint: Institute of Physics Publishing
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm, Spine: 33mm
Weight: 1.202kg
ISBN: 9780750308380
ISBN 10: 0750308389
Series: Series in Medical Physics and Biomedical Engineering
Pages: 638
Publication Date: 01 December 2003
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Hardback
Publisher's Status: Active

LIST OF CONTRIBUTORS, PREFACE, SECTION 1 INTRODUCTION, 1. ANATOMY, PHYSIOLOGY AND DISEASE, 1.1. Introduction, 1.2. Bone morphology and organization, 1.3. Bone tissue I: the role of bone cells, 1.3.1. The osteoclast, 1.3.2. The osteoblast, 1.3.3. The osteocytes, 1.4. Bone tissue II: the bony matrix, 1.5. Bone composition: mineralization of bone matrix, 1.6. Metabolic disorders of bone, 1.6.1. Introduction, 1.7. Osteoporosis, 1.7.1. Introduction, 1.7.2. Pathophysiology of osteoporosis, 1.7.3. Etiologic factors in osteoporosis, 1.7.4. Epidemiology, 1.8. Summary, References, 2. BIOLOGICAL SAFETY CONSIDERATIONS, 2.1. Introduction, 2.2. Duties and responsibilities, 2.3. Environmental protection, 2.4. Risk assessment, 2.5. Quantifying risk, 2.6. Acceptable risk, 2.7. Risk reduction, 2.8. Hierarchy of risk reduction, 2.9. Specific risks associated with the processing of bone, 2.9.1. Hazard identification, 2.10. Mechanical hazards, 2.10.1. Sawing bone, 2.10.2. Electrical hazards, 2.10.3. Chemical hazards, 2.11. Hazard identification, 2.11.1. Toxicity hazard, 2.11.2. Corrosive hazards, 2.11.3. Exposure limits, 2.11.4. Reactive hazards, 2.11.5. Flammability hazards, 2.12. Extinguishers, 2.13. Risk reduction and control: chemicals, 2.13.1. Fume cupboards, 2.13.2. Biological hazards, 2.14. Hazard categories of biological agents, 2.15. Hazard identification and hazard reduction at source, 2.15.1. For human bone, 2.15.2. For animal bone, 2.16. Prion diseases, 2.17. Biological control measures, 2.17.1. Allergens: control of exposure, 2.17.2. Microbiological safety cabinets, 2.17.3. Disinfectants, 2.17.4. Disinfection of cryostats, 2.17.5. Fumigation, 2.17.6. Disinfection of mechanical testing equipment and machine tools, 2.17.7. Autoclaves, 2.17.8. Disposal of biological waste, 2.17.9. Removal of equipment, 2.18. Use of personal protective equipment, 2.19. General managerial considerations, 2.19.1. Restricted access and permits to work, 2.19.2. Occupational health screening, 2.19.3

Dr Christian M Langton Centre for Metabolic Bone Disease, Hull Royal Infirmary, Anlaby Road, Hull HU3 2RW, UK Dr Christopher F Njeh The John Hopkins University, School of Medicine, Division of Radiation Oncology, The Harry and Jeanette Weinberg Building, 401 North Broadway, Suite 1440, Baltimore, MD 21231-1240, USA

Reviews for The Physical Measurement of Bone

A book of this nature is long overdue; as could be expected from the pedigree of the editors, the coverage is comprehensive and, thanks to the authors selected, is of high quality. The book is divided into five sections, the central three of which are concerned with the measurement techniques themselves... The invasive techniques of mechanical testing and bone histology are dealt with in great detail at a level suitable for postgraduate students looking for an introduction to these techniques at a practical level... this is an excellent and encyclopaedic book which any individual or department concerned with bone measurement, or wishing to extend their knowledge of the field, should have on their bookshelf. --J H Truscott, in Phys. Med. Biol. 49 (7 May 2004) 1833 I was impressed that there was enough known about bone measurement to fill over 600 pages. The book is short on history but strong on physical measurement of bone The book has 18 chapters in 4 sections with a total of 22 authors. Chapter 1 is on anatomy, physiology, and diseases of bone (with a heavy emphasis on osteoporosis). Chapter 2 on biological safety is twice as long as Chapter 3 on radiation safety. It was a pleasure to read a chapter on radiation safety without seeing any mention of risk The book describes in detail the following physical techniques to study bone in vivo: absorptiometry with radionuclide and x-ray sources; computed tomography (quantitative-QCT and peripheral- pQCT); radiogrammetry and in vivo activation analysis; magnetic resonance imaging; quantitative ultrasound; and vibration analysis. In vitro techniques include a description of (mu)CT of bone specimens, which show the beautiful detail oftrabecular bone from a tabletop instrument. Many chapters have over 100 references... For practical purposes the text has no competition. This book is a very thorough coverage of measurement of bones If you are doing research involving any measurement of bone it will be a valuable reference. -- J Cameron in Med. Phys. 31(6), June 2004