The Blood-Brain Barrier and Drug Delivery to the CNS

Michael Bradbury, David Begley, Jorg Kreuter

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English

CRC Press
05 September 2019

Medicine: general issues; Pathology

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques.

A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS

assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans

presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters

examines the multidrug resistance protein P-glycoprotein as a natural transporter

analyzes current drug designs to known requirements for transport

looks at drug delivery systems for the brain

and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

Edited by: Michael Bradbury, David Begley, Jorg Kreuter
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 229mm, Width: 152mm,
Weight: 494g
ISBN: 9780367398668
ISBN 10: 0367398664
Pages: 264
Publication Date: 05 September 2019
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Paperback
Publisher's Status: Active

David J. Begley, Michael W. Bradbury, Jörg Kreuter