Revival

Principles of Animal Extrapolation (1991)

Edward J. Calabrese (University of Massachusetts, Amherst, USA)

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English

CRC Press
29 January 2019

Toxicology (non-medical); Zoology & animal sciences; Pharmaceutical technology

Series: CRC Press Revivals

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis.

Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

By: Edward J. Calabrese (University of Massachusetts Amherst USA)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 453g
ISBN: 9781138561342
ISBN 10: 1138561347
Series: CRC Press Revivals
Pages: 616
Publication Date: 29 January 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Edward J. Calabrese is a board certified toxicologist who is Professor of Toxicology at the University of Massachusetts School of Pubic Health, Amherst. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants and is the author off more than 300 papers in scholarly journals, as well as 12 books.