This comprehensive textbook is the key resource for postgraduate trainees or residents in haematology. Now in its seventh edition, the book continues to provide everything the reader needs for examination preparation or clinical practice.
Postgraduate Haematology discusses up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style. It presents essential information for everyday use and teaching, as well more detailed scientific background for more in-depth reading, accompanied by thoughtful referencing.
The clearly illustrated full-colour figures and charts demonstrate key facts, and are supplemented by numerous high quality photomicrographs of blood cells and tissues. Over 51 chapters from international authors, including the WHO Classification of Haematopoietic and Lymphoid Tissues, Postgraduate Haematology provides an expert review of malignant and non-malignant haematology.
New sections reflect advances in the specialty, e.g. knowledge gained from new generation sequencing, latest anticoagulant drugs, diagnostic laboratory tools, and treatment strategies Superb four-color illustrations and photomicrographs of blood cells and tissues throughout Includes algorithms to aid with decision-making for treatment Companion website featuring figures and tables from the book
Arm yourself with the textbook of choice for trainees and practitioners in haematology.
Contributor List vii Preface to the Seventh Edition x Preface to the First Edition xi 1 Stem cells and haemopoiesis 1 Emma de Pater, Elaine Dzierzak 2 Erythropoiesis 11 Douglas R Higgs, Noémi Roy, Deborah Hay 3 Iron metabolism, iron deficiency and disorders of haem synthesis 21 Clara Camaschella, A Victor Hoffbrand, Chaim Hershko 4 Iron overload 40 Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini 5 Megaloblastic anaemia 53 A Victor Hoffbrand 6 Haemoglobin and the inherited disorders of globin synthesis 72 Swee Lay Thein, David Rees 7 Sickle cell disease 98 Anne Marsh, Elliott P Vichinsky 8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114 Paola Bianchi, Narla Mohandas 9 Acquired haemolytic anaemias 138 Modupe O Elebute, Rachel Kesse-Adu 10 Inherited aplastic anaemia/bone marrow failure syndromes 156 Inderjeet S Dokal 11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174 Judith CW Marsh, Austin G Kulasekararaj, Neal S Young, Peter Hillmen 12 Red cell immunohaematology 195 Geoff Daniels, Marcela Contreras, Shubha Allard 13 Clinical blood transfusion 214 Shubha Allard, Marcela Contreras 14 Phagocytes 246 John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman 15 Lysosomal storage disorders 270 Atul B Mehta, Derralynn A Hughes 16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278 Paul Moss, Mark Drayson 17 The spleen 303 Paul Moss 18 The molecular basis of haematological malignancies 314 Niccolo Bolli, George Vassiliou 19 Laboratory diagnosis of haematological neoplasms 332 Torsten Haferlach, Barbara J Bain 20 Acute myeloid leukaemia 352 Alan K Burnett, David Grimwade 21 Adult acute lymphoblastic Llukaemia 371 Clare J Rowntree, Adele K Fielding 22 Childhood acute lymphoblastic leukaemia 384 Ajay Vora 23 Supportive care in the management of leukaemia 399 Eliza Gil, Vanya Gant, Panagiotis Kottaridis 24 Chronic myeloid leukaemia 419 David TO Yeung, Timothy P Hughes 25 The myelodysplastic syndromes 438 Kavita Raj, Ghulam J Mufti 26 Myeloproliferative neoplasms 474 Peter J Campbell, Claire Harrison, Anthony R Green 27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500 Emili Montserrat, Peter Hillmen 28 T-cell lymphoproliferative disorders 524 Pier Luigi Zinzani, Alessandro Broccoli 29 Multiple myeloma 537 Jesús San-Miguel, Joan Bladé 30 Amyloidosis 562 Simon DJ Gibbs, Philip N Hawkins 31 The classification of lymphomas: updating the WHO classification 575 Elias Campo, Stefano A Pileri 32 Hodgkin lymphoma 601 Piers Blombery, David Linch 33 Non-Hodgkin lymphoma: low grade 614 William Townsend, Robert Marcus 34 Non-Hodgkin lymphoma: high grade 631 Jessica Okosun, Kate Cwynarski 35 Stem cell transplantation 651 Charles Craddock, Ronjon Chakraverty 36 Normal haemostasis 676 Keith Gomez, John H McVey 37 The vascular function of platelets 699 Stephen P Watson, Neil V Morgan, Paul Harrison 38 Haemophilia and Von Willebrand disease 715 Michael A Laffan, K John Pasi 39 Rare inherited coagulation disorders 733 Flora Peyvandi, Marzia Menegatti 40 Acquired coagulation disorders 743 Peter W Collins, Jecko Thachil, Cheng-Hock Toh 41 Congenital platelet disorders 761 Maurizio Margaglione, Paul RJ Ames 42 Primary immune thrombocytopenia 773 Drew Provan, Adrian C Newland 43 Thrombotic thrombocytopenic purpura and haemolytic–uraemic syndrome (congenital and acquired) 783 Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla 44 Heritable thrombophilia 795 Trevor Baglin, David Keeling 45 Acquired venous thrombosis 809 Beverley J Hunt, Henry G Watson 46 Antithrombotic agents 820 Trevor Baglin, David Keeling 47 Management of venous thromboembolism 830 Trevor Baglin, David Keeling 48 Haematologicalaspectsofsystemicdisease 838 A Victor Hoffbrand, Atul B Mehta 49 Haematological aspects of tropical diseases 854 Imelda Bates, Ivy Ekem 50 Neonatal haematology 870 Irene Roberts, Subarna Chakravorty 51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885 Index 888
A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci, Emeritus Professor of Haematology at University College London, London, UK. Douglas R. Higgs, MD, FRCP, FRS, Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK. David Keeling, Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK. Atul B. Mehta MA, MD, FRCP, FRC Path, Consultant Haematologist & Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK.
