Pathology of the Developing Mouse

A Systematic Approach

Brad Bolon (GEMpath Inc., Cedar City, Utah, USA)

$357

Hardback

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English

CRC Press Inc
24 April 2015

Medical research; Animal pathology & diseases; Zoology: Mammals

"Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a ""how to do"" manual for developmental pathology experimentation in mice but, more importantly, a ""how to interpret"" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity.

The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit:

baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids;

options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., ""lesions"") during development; and

well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta)."

Edited by: Brad Bolon (GEMpath Inc. Cedar City Utah USA)
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 254mm, Width: 178mm, Spine: 23mm
Weight: 1.088kg
ISBN: 9781420070088
ISBN 10: 1420070088
Pages: 446
Publication Date: 24 April 2015
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

GEMpath Inc., Cedar City, Utah, USA

Reviews for Pathology of the Developing Mouse: A Systematic Approach

Pathology of the Developing Mouse: A Systematic Approach is a much anticipated addition to the veterinary pathology reference literature. It is a fairly inexpensive textbook that will be useful for anyone who uses mice in developmental research. Detailed, easy-to-follow experimental protocols are described throughout the text. In many cases, there are multiple options for procedures with pros and cons discussed for each. Each chapter contains excellent tables, diagrams, and photographs and ends with a complete reference list. Although there is a growing volume of information on mouse developmental biology in the literature and on the Internet, the authors of this book have done a great job of creating a synopsis of this information that can be easily used by anyone working or training in mouse pathology or developmental biology. -Stephen M. Griffey, DVM, PhD, University of California-Davis, in JAVMA