Mechanobiology: From Molecular Sensing to Disease

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Glen L. Niebur (Professor of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN)

Mechanobiology

From Molecular Sensing to Disease

Glen L. Niebur (Professor of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN)

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English

Elsevier Science Publishing Co Inc
04 December 2019

Biophysics; Biochemistry

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.

By: Glen L. Niebur (Professor of Aerospace and Mechanical Engineering University of Notre Dame Notre Dame IN)
Imprint: Elsevier Science Publishing Co Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 191mm,
Weight: 520g
ISBN: 9780128179314
ISBN 10: 0128179317
Pages: 254
Publication Date: 04 December 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Section 1: Mechanobiological basis of diseases1.1 Osteoporosis1.2 Cardiovascular mechanics and disease1.3 Glaucoma and eye diseases1.4 Growth and development1.5 Tissue engineering and regenerative medicine Section 2: Cellular basis of Mechanobiology 2.1 Cells as strain gages and load cells2.2 Cell – extracellular matrix interactions2.3 Mechanobiological pathways2.4 Mechanically mediated epigenetics Section 3: Experimental methods3.1 Effects of shear stress on cells3.2 Three-dimensional culture systems3.3 Bioreactors3.4 Tissue and organ on a chip systems Section 4: Computational simulations in mechanobiology4.1 Cell aggregation4.2 Growth models5. Future prospects and challenges6. Bibliography7. Glossary

Glen Niebur is a professor of Aerospace and Mechanical Engineering at the University of Notre Dame. He holds bachelor’s and master’s degrees from the University of Minnesota, and the Ph.D. from the University of California. Research is focused on orthopedics, including bone quality, damage mechanics of trabecular bone, mechanobiology of bone, hard and soft tissue constitutive modeling, computational mechanics of tissues, and genetic factors affecting bone quality. Current projects are investigating the interactions between microdamage formation in bone and the changes in bone porosity and structure that accompany osteoporosis. Osteoporosis results in changes at multiple levels of the hierarchical structure of bone, and these can either compensate for or enhance fracture risk. Medical imaging methods, especially computed tomography (CT) are used to image and quantify bone structures in bone samples and in live animals. A current project is using medical imaging to longitudinally monitor and understand fracture healing. Most recently, work has begun in the area of bone marrow mechanics, affects of aging and disease on bone marrow morphology, and interactions between bone and bone marrow.