Malignant pleural mesothelioma, a malignancy due largely to asbestos exposure, represents an increasingly common challenge to clinical and medical oncologists, respiratory physicians, and cardiothoracic surgeons, as well as researchers in the field. The disease has yet to reach its peak and is expected to kill over 100,000 people worldwide. As malignant pleural mesothelioma gains in profile, Kenneth O'Byrne and Valerie Rusch present a comprehensive overview of the subject, aimed at all health care professionals who come into contact with patients with the disease.
The book includes chapters on epidemiology, diagnosis, histopathology, radiology, surgery, chemotherapy, immune therapy, radiotherapy, and palliative medicine, written by an international team of contributors. A molecular biology section focuses on the carcinogenic effects of asbestos fibres and simian virus 40, angiogenesis and angiogenic growth factors, the immune response, and genetic abnormalities detected in the disease. Future therapies are also covered, as is a perspective on the distinct legal issues related to the disease. This highly-illustrated, full colour book provides the ultimate, timely resource on this devastating disease.
Section 1. Clinical Features of Mesothelioma 1: Juliet E King & Philip S Hasleton: The Epidemiology and Aetiology of Malignant Mesothelioma 2: AW Musk, NH de Klerk, Jacek Niklinski, Wieslawa Niklinska, Elzbieta Chyczewska, Jerzy Laudanski, Wojciech Naumnik, Lech Chyczewski, Eric Pluygers, Raymond P Abratt, Daniel A Vorobiof, Neil White, Salih Emri, Murat Tuncer & Izzettin Baris: Epidemiological Snapshots From Around the World 3: Michael D Peake & James Entwisle & Steven Gray: Clinical Presentation, Radiological Evaluation and Diagnosis 4: Juliet King, Françoise Galateau-Sallé & Philip Hasleton: Histopathology of Malignant Pleural Mesothelioma 5: J.A Burgers & J.P.J.J Hegmans: Clinico-Pathological Prognostic Factors & Scoring Systems in Malignant Pleural Mesothelioma Section 2. Biology of Mesothelioma 6: BT Mossman & William Swain: Carcinogenic Mechanisms in Mesothelioma: Effects of asbestos on cell signal events, transcription factors, and inflammatory cytokines 7: Amy Powers, Maurizio Bocchetta & Michele Carbone: Viral Factors in the Pathogenesis of Malignant Mesothelioma 8: John G Edwards, Uwe Zangemeister-Wittke & Kenneth J O'Byrne: Growth Factors, Cyclooxygenease-2 and Matrix Metalloproteinases in Malignant Mesothelioma 9: Peter B Vermeulen, Roberto Salgado & Eric A Van Marck: Vascularisation in Malignant Mesothelioma 10: AM Smith, S Lansley, C Jackaman, B Koloska, S Broomfield, Bruce W.S Robinson & D.J Nelson: Immunobiology of Malignant Mesothelioma 11: Deborah A Altomare & Joseph R Testa: Cytogenetic and Molecular Genetic Changes in Malignant Mesothelioma Section 3. Treatment Strategies 12: David A Waller & Antonio E Martin-Ucar: The Role of Surgery for Diagnosis, Staging and Symptom Control in Malignant Pleural Mesothelioma 13: Daniel J Boffa & Valerie W Rusch: Surgical and Multimodality Approaches to the Management of Operable Malignant Mesothelioma 14: Jeremy P.C Steele & Robin M Rudd: Systemic Chemotherapy for Malignant Pleural Mesothelioma 15: Craig W Stevens, Kenneth M Forster & W. Roy Smythe: Radiotherapy for Mesothelioma 16: Mary ER O'Brien, Ander Urruticoechea Ribate & Bernard Souberbielle: Immunotherapy for Malignant Mesothelioma 17: Paul Baas: Intra-thoracic Photodynamic Diagnosis and Treatment with Photodynamic Therapy or Hyperthermia of Malignant Mesothelioma 18: Fiona Blackhall, Sofia Baka, Sarah Danson and Malcolm Ranson: Novel Therapies for Mesothelioma 19: Daniel H Sterman & Peter A DeLong: Gene Therapy for Malignant Pleural Mesothelioma 20: Sam Ahmedzai & Helen Clayson: Palliative Care for Mesothelioma 21: Adrian Budgeon & John Ned Lipsitz: The Treatment of Mesothelioma Cases in the American and United Kingdom Legal Systems
Dr Ken O'Byrne is President of the British Mesothelioma Trust. Professor Valerie Rusch, M.D. is currently Chief of Thoracic Surgery at Memorial Sloan-Kettering Cancer Center, where she also holds the William G. Cahan Chair. She is a member of the Editorial Boards for The Journal of Thoracic and Cardiovascular Surgery, The Journal of Clinical Oncology, The Oncologist, and Lung Cancer.
Reviews for Malignant Pleural Mesothelioma
<br> Anybody dealing with diffuse malignant mesothelioma, in either a research or clincial setting, should learn a great deal from this book in topics outside his or her own immediate specializations. As this clinically relentless disease continues to increase but has proven so refractory to therapy, any additional knowledge is welcome ideed, and this book is also welcome indeed. --Respiratory Care<br> A comprehensive overview of the subject, aimed at all health care professionals who come into contact with patients with the disease. --Anticancer Research<br>