Intra-uterine insemination (IUI) is a widely used fertility treatment for couples with unexplained and male subfertility. Although it is less invasive and less expensive as athan several other treatment options, than in vitro fertilization, severalsome points about the factors affecting its outcomeIUI remain controversial and there remains concern about some of the possible aspects of treatmentside-effects, such as an increase in multiple pregnancy rates. This is a comprehensive evidence-based book from an international IUI expert team, with guidelines for daily practice clearly stated and summarized for readers’ convenience.
General Introduction to Intra-Uterine Insemination (IUI) as a Treatment for Subfertility: The Impressions of an Old-Timer. Diagnostic Work-Up before IUI. When to Start IUI? Indications for IUI. Immunologic Male Infertility. Factors Influencing IUI Outcome: Female Age. Factors Influencing IUI Outcome: Male Age. Factors Influencing IUI Outcome: Weight Influences. Factors Influencing IUI Outcome: Semen Quality. Factors Influencing IUI Outcome: Semen Preparation Techniques. Factors Influencing IUI Outcome: Time Interval as a Prognostic Factor. Factors Influencing IUI Outcome: Number of Cycles to Perform. Factors Influencing IUI Outcome: Perifollicular Flow and Endometrial Thickness. Factors Influencing IUI Outcome: Timing and Number of Inseminations per Cycle. Factors Influencing IUI Outcome: Site of Insemination in Therapeutic Donor Insemination. Factors Influencing IUI Outcome: Immobilization after IUI. Factors Influencing IUI Outcome: Ovarian Hyperstimulation. Factors Influencing IUI Outcome: Luteal Phase Support. Fallopian Sperm Perfusion: Evidence on IUI versus Fallopian Sperm Perfusion. Media Supplements: Platelet Activating Factor Improves Sperm Motility and IUI Outcomes. Oxidative Stress and IUI Outcomes. Cost-Effectiveness of IUI. Minimal Standards and Organization for Donor Sperm Banking. Indications for Donor Sperm Including Lesbian Couples and Single Women. IUI and Psychological Aspects. Risk Factors for Higher-Order Multiple Pregnancies Following Stimulated IUI. Prevention of Multiple Pregnancies after IUI. Perinatal Outcome after IUI. IUI-Associated Infection Risks and Preventative Measures. Cancer and Semen Preservation. Preconception Gender Selection: Laboratory Aspects. Preconception Sex Selection: Ethical Evaluation. Factors Affecting the Success of IUI: Implications for Developing Countries. SWOT Analysis of Accessible IUI in Developing Countries, Resource-Poor Settings, and Primary Care Centers.
Ben Cohen, Willem Ombelet
