Describing information on the pathogenesis and molecular biology of human papillomaviruses, this text also describes the mechanistic role of the viruses in epithelial cancers. Included in the volume are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are also discussed.
Preface. Clinical Aspects and Epidemiology of HPV Infections (C.M. Wheeler). Regulation of Human Papillomavirus Gene Expression in the Vegetative Life Cycle (L. del Mar Pena, L.A. Laimins). Human Papillomavirus DNA Replication (Jen-Sing Liu, T. Melendy). Human Papillomavirus E6 Protein Interactions (M. Thomas, D. Pim, L. Banks). The Biology of E7 (D.J. McCance). Biology of the E4 Protein (S. Roberts). The E5 Protein of Papillomaviruses (A. Venuti, M. Saveria Campo). Human Papillomaviruses Immunology and Vaccine Development (R. Rose). Summary - What we need to learn (D.J. McCance). List of Addresses.