Furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Contains contributions by
eminent international figures in the field, including Nobel
Laureate in Medicine, Dr. Andrew V. Schally.
By:
Barry B. Bercu,
Richard F. Walker
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions:
Height: 229mm,
Width: 152mm,
Spine: 30mm
Weight: 771g
ISBN: 9780824798321
ISBN 10: 0824798325
Pages: 462
Publication Date: 28 April 1998
Audience:
College/higher education
,
Professional and scholarly
,
Further / Higher Education
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Part 1 Scope of non-GHRH growth hormone secretagogues: synergistic release of growth hormone by GHRP and GHRH - scope and implication; structural requirements of growth hormone secretagogues; unifying mechanism of non-GHRH growth hormonesecretagogues's action; molecular cloning and characterization of human, swine and rat growth hormone secretagogues receptors; a mathematical model for growth hormone release from the pituitary; evidence for a new subtype of GHRP receptors in ovinepituitary gland. Part 2 Experimental pharmacology: agonists analogs of growth hormone-releasing hormone - endocrine and growth studies; antagonistic analogs of growth hormone-releasing hormone - endocrine and oncological studies; clinical evidence forextrahypophyseal site of growth hormone secretagogues; electrophysiological studies of the arcuate nucleus - central actions of growth hormone secretagogues; effects of a growth hormone-releasing peptide-like nonpeptidyl growth hormone secretagogue onphysiology and function on aged rats; anterior pituitary function in prolonged critical illness - effects of continuous infusion of growth hormone secretagogues; hepatic extraction of hexarelin, a new peptide growth hormone secretagogue, in the isolatedperfused rat liver; the effect of growth hormone secretagogues on the release of growth hormone-releasing hormone, somatostatin, vasopressin and corticotrophin-releasing hormone from the rat hypothalamus in vitro; immunocytochemical studies investigatingthe central actions of the nonpeptidyl growth hormone secretagogue, MK-0677. Part 3 Clinical applications of growth hormone secretagogues: evaluation of pituitary function using growth hormone secretagogues; clinical use of growth hormone secretagogues;short- and long-term growth hormone secretagogue administration in children; endocrine response to growth hormone-releasing peptides across human life span; GHRH and GHRP-5 exert different effects on sleep electroencephalograms and nocturnal hormonesecretion in normal men. (Part contents).
Bercu, Barry B.; Walker, Richard F.
