Duchenne Muscular Dystrophy: Advances in Therapeutics

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Jeffrey S. Chamberlain (University of Washington, Seattle, USA) Thomas A. Rando (Stanford University, Palo Alto, California, USA)

Duchenne Muscular Dystrophy

Advances in Therapeutics

Jeffrey S. Chamberlain (University of Washington, Seattle, USA), Thomas A. Rando (Stanford University, Palo Alto, California, USA), Roula Al-Dahhak (The Ohio State University, Columbus, Ohio, USA) , Thomas A. Rando (Stanford University, Palo Alto, California, USA)

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English

CRC Press Inc
27 February 2006

Hereditary diseases & disorders; Musculoskeletal medicine; Neurology & clinical neurophysiology

Series: Neurological Disease and Therapy

Duchenne Muscular Dystrophy (DMD) is one of the most prevalent genetic disorders of childhood and currently stands as an incurable condition. This authoritative guide provides a clear overview of the latest current and experimental approaches to the treatment of DMD and examines the clinical, genetic, and pathophysiological aspects of the disease in the context of emerging therapeutic modalities. The only available source on the subject, this reference emphasizes the importance of accurate diagnosis, carrier detection, and genetic counseling, and supplies state-of-the-art contributions on pharmacological interventions, regenerative medicine, and gene therapy.

Contributions by: Roula Al-Dahhak (The Ohio State University Columbus Ohio USA), Carmen Bertoni (Stanford Univ School of Med, Stanford, California, USA)
Edited by: Jeffrey S. Chamberlain (University of Washington Seattle USA), Thomas A. Rando (Stanford University, Palo Alto, California, USA), Thomas A. Rando (Stanford University, Palo Alto, California, USA)
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 28mm
Weight: 793g
ISBN: 9780824723255
ISBN 10: 0824723252
Series: Neurological Disease and Therapy
Pages: 496
Publication Date: 27 February 2006
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Clinical Overview. The Functional Biology of Dystrophin. Duchenne Muscular Dsytrophy and Becker Muscular Dystrophy: Diagnostic Principles. Mutation Detection. Protein Studies. Medical Management. Rehabilitation Management. A Review of Current Practice and Clinical Outcomes. Therapeutic Principles and Challenges. Experimental Pharmacologic Therapies. Utrophin: The Intersection between Pharmacological and Genetic Therapy. Regenerative Therapy. Cellular-Mediated Delivery: The Intersection between Regenerative Medicine and Genetic Therapy. Oligonucleotide-Mediated Rxon Skipping and Gene Editing. Intravascular Delivery of Naked DNA. Adenoviral-Mediated Gene Therapy. Retroviridae-based Gene Transfer Vectors. Gene Therapy Using Adeno-Associated Viral Vectors. Regional and Systemic Gene Delivery using Viral Vectors.

Jeffrey S. Chamberlain, Thomas A. Rando