Drug Repositioning

This excellent book is a must read for those interested in drug-repositioning and those involved in the hunt for new effective neurotherapeutics. The introductory sections of the book provide not only a clear explanation of the merits of repositioning but also an honest consideration of the difficulties of the approach. This is well illustrated by examples from the fields of Alzheimer's and Parkinson's describing successes and failures. Also introduced is the value of drug-repositioning to not-for profit organisations. Which adds to those who are involved in medical charity research to list of those who should read this publication. For the reader whose interest is piqued by the possibilities of drug repositioning and want to know more of the mechanics following chapters explore a variety of techniques that can be adopted for the identification of candidate repositioned therapies. Again, these an honest consideration with both pro and cons described. This makes the publication useful reading for any interested in repositioning irrespective of their field of interest. The latter sections focus on repositioning for a very diverse range of CNS conditions. These include Parkinson's, Alzheimer's, Huntingdon's, ALS, Spinal muscular atrophy and Ischaemic injury. For those with specific interests in any of the above this is a useful work. But in addition, I would recommend to those with a specific CNS disease interest reading the other chapters as they provide a potentially useful insight into methods and approaches than could be adopted within a specific interest. Taken together this is valuable read and reference work for a diverse readership. - Dr Alan Rothaul, Re-Pharm Drug repositioning, also known as repurposing, seems an easy and straight forward route for the successful development of drugs. However, aspects of value creation and sound business cases are still essential, eve