This volume examines the enhancement of high-performance liquid chromatography through the development of an advanced mode of electrochemical detection (ECD) - the coulometric electrode array - from its initial promising, yet problematic, amperometric (thin-layer) design to the highly sensitive, selective and stable coulometric (flow-through) design. Unlike amperometric electrodes, the coulometric electrode is 100 per cent efficient, and measures signals from all of the analyte passing through it, which leads to improved sensitivity as well as unique selectivity. The coulometric electrode array offers the resolution of the photodiode array with the extreme sensitivity of an electrochemical detector. The book examines the use of the coulometric electrode array, as well as its practical applications in neurosciences, food, environmental, pharmaceutical and agricultural sciences and those in the area of oxidative metabolism. This collection of papers should also provide a useful reference source to all workers in the field of HPLC and those using electrochemical detection.
Edited by:
Acworth,
Naoi,
Hasan Parvez,
Mikhailov,
S. Parvez
Imprint: VSP International Science Publishers
Volume: 6
Dimensions:
Height: 246mm,
Width: 174mm,
Spine: 21mm
Weight: 679g
ISBN: 9789067642323
ISBN 10: 9067642320
Series: Progress in HPLC-HPCE
Pages: 382
Publication Date: 23 May 2001
Audience:
College/higher education
,
Professional and scholarly
,
Further / Higher Education
,
Undergraduate
Format: Paperback
Publisher's Status: Active
Preface, AN INTRODUCTION TO HPLC BASED ELECTROCHEMICAL DETECTION FROM SINGLE ELECTRODE TO MULTI-ELECTRODE ARRAYS; THEORETICAL AND APPLIED ASPECTS; HPLC WITH ELECTRODE ARRAY DETECTION AND ITS APPLICATION IN ANALYTICAL FOOD CHEMISTRY; THE MEASUREMENT OF MARKERS OF OXIDATIVE DAMAGE, ANTI-OXIDANTS AND RELATED COMPOUNDS USING HPLC AND COULOMETRIC ARRAY ANALYSIS; CEA S GENERATION OF LARGE MULTI-PARAMETER METABOLIC DATABASES FOR DETERMINING CATEGORICAL PROCESS INVOLVEMENT OF BIOLOGICAL MOLECULES; THE APPLICTAION OF EC-H PLC TO THE ANALYSIS OF INSECT BIOGENIC AMINES; A PHYLOGENETIC ANALYSIS OF BIOGENIC MONOAMINES IN THE CENTRAL NERVOUS SYSTEMS OF VARIOUS ORGANISMS AND APPLICATION TO THE FIELDS OF MEDICAL BIOCHEMISTRY; MULTI-COMPONENT QUANTITATIONS OF MONOAMINES AND RELATED COMPOUNDS IN BIOLOGICAL FLUIDS AND CNS TISSUES BY HPLC COUPLED WITH MULTI-ELECTRODE ELECTROCHEMICAL DETECTION; THE APPLICATIO PF THE MUTLI-ELECTRODE DETECTION SYSTEM TO NEUROCHEMISTRY: IN VIVOMICRODIALYSIS STUDIES; Part Contents
I.H. Acworth, M. Naoi, Hasan Parvez, S. Parvez
