Colony-Stimulating Factors

Molecular & Cellular Biology, Second Edition,

John M. Garland, Peter J. Quesenberry, Douglas J. Hilton , Douglas J. Hilton

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English

CRC Press Inc
16 May 1997

Cytology; Molecular biology; Cellular biology (cytology)

Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.

By: John M. Garland
Edited by: Peter J. Quesenberry, Douglas J. Hilton, Douglas J. Hilton
Imprint: CRC Press Inc
Country of Publication: United States
Edition: 2nd edition
Dimensions: Height: 254mm, Width: 178mm, Spine: 34mm
Weight: 1.179kg
ISBN: 9780824794927
ISBN 10: 0824794923
Pages: 580
Publication Date: 16 May 1997
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Hardback
Publisher's Status: Active

Overview: introduction to the haematopoietic system; surrogate assays for haematopoietic stem cell activity; receptors for haematopoietic regulators; regulation of the cell cycle by kinases and cyclins; gene organization and regulation; cytokines and apoptosis - the mechanism of regulation of cell death; haematopoietic microenvironments; extracellular matrix- and membrane-bound cytokines; transfection of stem cells and gene therapy. Colony-stimulating factor: granulocyte-macrophage colony-stimulating factor and its receptor; granulocyte colony-stimulating factor; human interleukin-3 - an overview; macrophage colony-stimulating factor; erythropoietic; the role of interleukin-4 in normal and malignant human haematopoietic effects of interleukin-1; kit-ligand-stem cell factor; interleukin-5. Cytokines: macrophages inflammatory protein-1 alpha; transforming growth factor-beta, tumour necrosis factor-alpha, and macrophage inflammatory protein-1 alpha are bidirectional regulators of haematopoietic cell growth; leukaemia inhibitory factor; interleukin-12 in haematopoiesis; ex vivo expansion of haematopoietic stem and progenitor cells; clinical use of cytokines.

John M. Garland\,

Reviews for Colony-Stimulating Factors: Molecular & Cellular Biology, Second Edition,

International Praise for the First Edition. . . . . .a very useful resource book. . .The best chapters are full of insights that will continue to be useful for years to come. ---The Quarterly Review of Biology . . .provide[s] a useful perspective in what is a rapidly moving field. ---Trends in Biochemical Science . . .a remarkable book. . . . . .strongly recommend[ed]. . .It is up to date and contains information and references which everyone working in any aspect of bone marrow biology should have at hand. ---Biologist . . .an excellent compilation of modern knowledge concerning hematopoiesis and the colony-stimulating factors taken from a basic science to a clinical perspective. ---American Journal of Physiology . . .an excellent coverage of the field. ---Hematologic Pathology . . .an exciting volume. ---Cell