Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment.
Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information and hopefully also inspiration to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers
List of Contributors, ix Preface, xiii Part I Foundations of Biomarker Research 1 Nuts and Bolts of Biomarker Research, 3 Sharmistha Ghosh and Sudhir Srivastava 2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16 Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi 3 MicroRNA Biomarkers for Early Detection of Cancer, 27 WendyWang, Matthew R Young, and Sudhir Srivastava 4 Inflammation and Cancer, 37 Pamela L Beatty, Sandra Cascio, and Olivera J Finn 5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50 Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava 6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64 Elisa CWoodhouse and Suresh Mohla Part II State-of-the-Science in Organ-Specific Biomarker Research 7 Breast Cancer, 77 Benjamin A Katchman, Christos Patriotis, and Karen S Anderson 8 Ovarian Cancer, 93 Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates 9 Esophageal Cancer Biomarkers, 104 Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady 10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118 Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani 11 Pancreatic Cancer, 130 Sam CWang and Peter J Allen 12 Colon Cancer, 141 Paul DWagner 13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151 Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava 14 Early Detection of Lung Cancer, 163 Mohamed Hassanein, Melinda C Aldrich, Stephen A Deppen, Karl E Krueger, Eric L Grogan, and Pierre P Massion 15 Commonalities in Lung Cancer and COPD, 185 MalgorzataWojtowicz and Eva Szabo 16 Prostate Cancer, 197 Jacob Kagan, Ian M Thompson, and DanielWChan Part III Biomarkers, Screening and Precision Health: Implications for Public Health 17 Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209 David F Ransohoff 18 Cancer Overdiagnosis, Ramifications and Research Strategies, 220 Barbara K Dunn and Barnett S Kramer 19 Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231 Brian S Sorg, Sarfraz Memon, Kelly Y Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C McKee, Barbara A Conley, and J Milburn Jessup 20 Statistical Consideration in Predictive and Prognostic Markers, 245 Fei Ye and Yu Shyr 21 Clinical Validation of Molecular Biomarkers in Translational Medicine, 256 Harry B Burke and William E Grizzle 22 Cancer Biomarker Assays: Performance Standards, 267 Anna K Fuzery and Daniel W Chan 23 Bioethics and Cancer Biomarker Research, 277 Nathan Nobis, William Grizzle, and Stephen Sodeke 24 Colon Cancer Screening, 283 Molly Perencevich, Jennifer Inra, and Sapna Syngal
Edited by Sudhir Srivastava, Ph.D., MPH Senior Scientific Officer, Chief, Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Translational Oncology Series Series Editors ROBERT C. BAST, MD, Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA MAURIE MARKMAN, MD, Senior Vice President for Clinical Affairs, Cancer Treatment Centers of America, Clinical Professor of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA ERNEST HAWK, MD, MPH, Vice President, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
