Biological Small Angle Scattering: Theory and Practice

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Eaton E. Lattman (Professor of Structural Biology, Professor of Structural Biology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY) Thomas D. Grant (Staff Scientist, Staff Scientist, BioXFEL Science and Technology Center, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY)

Biological Small Angle Scattering

Theory and Practice

Eaton E. Lattman (Professor of Structural Biology, Professor of Structural Biology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY), Thomas D. Grant (Staff Scientist, Staff Scientist, BioXFEL Science and Technology Center, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY), Edward H. Snell (President and Chief Executive Officer, President and Chief Executive Officer, Hauptman-Woodward Medical Research Institute)

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English

Oxford University Press
02 August 2018

Biophysics; Crystallography; Molecular biology

Series: International Union of Crystallography Monographs on Crystallography

Small angle solution scattering (SAS) is increasingly being applied to biological problems. It is a complementary technique that, when applied in appropriate circumstances with carefully structured questions, can provide unique information not available from other techniques. While small angle solution scattering has been around for some time, a confluence of recent developments has dramatically enhanced its power. Intense third generation X-ray sources, low noise detectors, development of new algorithms and the computational power to take advantage of these have all matured, and use of free-electron x-ray laser sources is on the horizon.

Whole new classes of experiments and analyses have been created as a result.

These include the generation of molecular envelopes, the ability to do time-resolved studies, and the ability to account for structural changes using modelling based on the SAS data. The technical improvements have also reduced the amount of time and material needed to carry out an experiment. Beamtime at synchrotron sources is in demand, workshops on the subject are popular and researchers adopting the technique as part of their repertoire are growing. With these in mind, this book was written to guide structural biologists who may wish to adopt the technique, understand its strengths and weaknesses or just have a general interest in its potential.

By: Eaton E. Lattman (Professor of Structural Biology Professor of Structural Biology School of Medicine and Biomedical Sciences University at Buffalo SUNY), Thomas D. Grant (Staff Scientist, Staff Scientist, BioXFEL Science and Technology Center, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY), Edward H. Snell (President and Chief Executive Officer, President and Chief Executive Officer, Hauptman-Woodward Medical Research Institute)
Imprint: Oxford University Press
Country of Publication: United Kingdom
Volume: 29
Dimensions: Height: 237mm, Width: 164mm, Spine: 20mm
Weight: 1g
ISBN: 9780199670871
ISBN 10: 0199670870
Series: International Union of Crystallography Monographs on Crystallography
Pages: 284
Publication Date: 02 August 2018
Audience: College/higher education , A / AS level , Further / Higher Education
Format: Hardback
Publisher's Status: Active

PART I: INTRODUCTION 1: Introduction PART II: THEORY OF SMALL ANGLE SCATTERING 2: Theoretical Background 3: Quantities directly measurable by Scattering 4: Three-Dimensional Modeling of SAXS Data PART III: PRACTICAL ASPECTS OF SMALL ANGLE SCATTERING 5: Before the beamtime 6: During the beamtime 7: Analysis after the beamtime 8: Worked Examples of Data Collection, Processing, and Analysis 9: Dealing with imperfect samples 10: SAXS Instrumentation 11: High-throughput approaches to SAXS 12: Small Angle Neutron Scattering PART IV: APPLICATIONS PAST, PRESENT, AND FUTURE 13: Examples of Biological Small Angle Scattering 14: Developments on the Horizon 15: Epilogue

Eaton Lattman received a BA degree from Harvard College in Chemistry and Physics, and a PhD degree from the Johns Hopkins University in Biophysics. He went on to spend many years at Johns Hopkins, rising through the ranks to become Professor, Departmental Chair, and Dean of Research and Graduate Education. He is currently Professor of Structural Biology in the School of Medicine and Biomedical Sciences, University at Buffalo, SUNY. He has published many papers in the area of structural biology, including a number on methods development. Thomas Grant received a B.S. degree from the University at Buffalo in Mathematical Physics and a PhD from the University at Buffalo in Structural Biology. After a post-doc at the Hauptman-Woodward Institute, he became a Staff Scientist as part of the NSF Science and Technology Center known as BioXFEL through the University at Buffalo. Edward Snell is President and Chief Executive Officer at the Hauptman-Woodward Medical Research Institute in Buffalo, NY, and Bioinnovations Professor at the University of Buffalo, SUNY.

Reviews for Biological Small Angle Scattering: Theory and Practice

The text is well written and easy to read, with each chapter concluding with a helpful summary. Overall, the book provides a description of biomolecular small-angle scattering and its applications that complements other texts and, when used in combination with established quality reference texts that are well referenced in this new contribution, would be useful for both the novice and expert scatterer * Acta Crystallographica *