Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers

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Morten Karsdal (CEO, Nordic Bioscience A/S, Herlev, Denmark)

Biochemistry of Collagens, Laminins and Elastin

Structure, Function and Biomarkers

Morten Karsdal (CEO, Nordic Bioscience A/S, Herlev, Denmark)

$247.95

Paperback

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English

Academic Press Inc
29 May 2019

Proteins

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix.

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease.

By: Morten Karsdal (CEO Nordic Bioscience A/S Herlev Denmark)
Imprint: Academic Press Inc
Country of Publication: United States
Edition: 2nd edition
Dimensions: Height: 229mm, Width: 151mm,
Weight: 660g
ISBN: 9780128170687
ISBN 10: 0128170689
Pages: 434
Publication Date: 29 May 2019
Audience: Professional and scholarly , Undergraduate
Replaced By: 9780443156175
Format: Paperback
Publisher's Status: Active

Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010. Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.

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Biochemistry of Collagens, Laminins and Elastin

Structure, Function and Biomarkers

Morten Karsdal (CEO, Nordic Bioscience A/S, Herlev, Denmark)

$247.95

Paperback

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