This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems
discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology
analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces
covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions
examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles
describes vaginal, nasal, buccal, ocular, and transdermal drug delivery
reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts
explores issues of product development, clinical testing, and production
and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologist
Edited by:
Edith Mathiowitz,
Donald E. Chickering III,
Claus-Michael Lehr
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions:
Height: 234mm,
Width: 156mm,
Weight: 453g
ISBN: 9780367399603
ISBN 10: 0367399601
Pages: 696
Publication Date: 07 October 2019
Audience:
College/higher education
,
Professional and scholarly
,
Primary
,
Undergraduate
Format: Paperback
Publisher's Status: Active
Fundamentals of Bioadhesion Definitions, Mechanisms, and Theories of Bioadhesion Donald E. Chickering III and Edith Mathiowitz The Role of Water Movement and Polymer Hydration in Mucoadhesion John D. Smart A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels Carla Marcella Caramella, Silvia Rossi, and Maria Cristina Bonferoni Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina Udo Schumacher and Dietlind Schumacher Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins Barry James Campbell Methods of Evaluating Bioadhesive Interactions Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres Donald E. Chickering III, Camilla A. Santos, and Edith Mathiowitz Novel Magnetic Technique to Measure Bioadhesion Benjamin A. Hertzog and Edith Mathiowitz Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems Michael Horstmann, Walter Müller, and Bodo Asmussen Force Microscopy of Cells to Measure Bioadhesion E. zur Mühlen, P. Koschinski, S. Gehring, Robert Ros, Louis Tiefenhauer, Eleonore Haltner, Claus-Michael Lehr, Uwe Hartmann, Falk Schwesinger, and A. Plückthun Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems James Schneider and Matthew Tirrell A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction Cheng Zhu, James W. Piper, and Robert A. Swerlick Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems Multifunctional Polymers for the Peroral Delivery of Peptide Drugs Henrik L. Luessen, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, Bas J. de Leeuw, Gerrit Borchard, and Claus-Michael Lehr Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia A. F. Kotzé, Henrik L. Luessen,
Edith Mathiowitz, Donald E. Chickerin III, Claus-Michael Lehr
Reviews for Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development
This comprehensive, multi-author volume would form an excellent starting point for researchers, students and industrial scientists keen to familiarize themselves with this field. This book, a welcome addition to the series 'Drugs and the Pharmaceutical Sciences', will provide excellent background and, indeed, might almost be regarded as a manual for those working in this areas. - Retinoids & Lipid-Soluable Vitamins in Clinical Practice excellent. very interesting and certainly stimulating. The authors and the editors are to be congratulated for providing a valuable and timely review of a new development subject. -Pharmaceutical Technology
